|
KMID : 0370219970410020174
|
|
Yakhak Hoeji
1997 Volume.41 No. 2 p.174 ~ p.180
|
|
|
Synthesis of N-[2-(3,5-dimethyl-4-methoxypyridyl)alkyl]oxazolidinone Analogues and Evaluation of their Proton Pump Enzyme Inhibitions
|
|
윤성화/Yoon SH
김도영/황성관/Kim DY/Hwang SK
|
|
|
Abstract
|
|
|
|
Four oxazolidinone analogues(6, 7, 8, 9), which are isosters of 5, were synthesized by the reaction of 2-chloroalkyl-3,5-dimethyl-4-methoxypyridine with the corresponding benzoxazolidinone or oxazolidinone, respectively, and were evaluated for their inhibitory activities toward proton pump enzyme under in vitro condition. Isosteric substitution of the benzothiazolidine moiety in 5 with benzoxazolidinone rendered the molecule relatively inactive.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|